PharmaCore Labs (PCL) Co., Ltd is a Chinese-foreign joint venture enterprise founded in 2013. The company is located inside the Haimen Biotech and Pharmaceutical Park of the Riverside New District in Jiangsu Province. The park covers an area of 500 acres with a total planned construction area of 320,000 square meters and is suitable for scientific research and development, business incubation, service outsourcing, product testing, and GMP factory. PCL also has two branch offices in Shanghai, China, and in New York, USA. The company is founded by several returned overseas doctors with rich working experience in the pharmaceutical companies in the US, and 50% of staff members hold master degrees and above. PCL is the first company available in China to provide complete pre-clinical cardiac safety assessment platforms an...
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Reaction Biology Corporation is an industry leader and innovator specializing in assay services and protein production for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust biochemical, biophysical, electrophysiological and cell assay technologies for high throughput screening (HTS) and selectivity compound profiling. RBC's target covering is wide, covering more than 1000 different targets, heavily focused on kinase and epigenetic targets. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Every year there are over 750 clients worldwide, including pharmaceuticals, biotechs. Academic and nonprofit laboratories utilizing our drug discovery services and produ...
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CiPA panel In vitro cellular level Tissue/organ level In vivo whole animal level
Stable cell lines Primary cells Brain slice electrophysiology Animal disease models
Target Validation Hit Identification Hit to Lead Lead Optimization
Normally it takes about 7-10 working days for those in vitro patch clamp routine assays such as hERG assay, Nav1.5 assay after test compounds are received. For action potential recording and Langendorff isolated perfused heart, it takes about 10-12 workin
PharmaCore Labs use guinea pigs, rabbits or rats to harvest cardiomyocytes and for action potential recording in Purkinje fibres and langendorff isolated perfused heart.
No. Currently the assays in PharmaCore Labs are not GLP-compliant, but follow GLP-similar guidelines.
