Hit Identification - PharmaCore Labs (PCL) Co., Ltd




Main Office, PCL

Address: Haimen Biotech and Pharmaceutical Park, Riverside New District, Haimen, Jiangsu Province, China

Tel:+86 0513 68015200

Website: www.pharmacorelab.com

Branch Office, PCL

Address: Block 6D, 780 Cailun Road, China (Shanghai) pilot free trade zone. infor@pharmacorelab.com

Hit Identification

Your current location: Home > SERVICE > Preclinical drug discovery  > Hit Identification

Hit Identification

Time2020-04-23 16:52:40 Hits1006

Reaction BiologyReaction Biology is world leader in kinase and epigenetic drug discovery research–excellence due to gold standard assay formats with high reproducibility and low false positive/negative counts

Over 1,000 validated assays are available for high throughput screening based on

Our experienced assay development team will realize all steps necessary for your customized screening project including

• Enzymatic activity

• Protein-protein interaction

• Biophysical binding

• Membrane binding

• Cell-based receptor functions

• Construct selection

• Molecular cloning

• Protein production and purification

• Substrate identification

• Assay development and optimization

• Primary, secondary and counter screenings

Hit Evaluation via Secondary and Orthogonal Screening

• Validate primary hits by IC50 value determination

• Identify false positives/negatives by use of a second assay format

• Get more knowledge about the compound-target interaction such as kinetic data

• Use cell-based activity assays to validate the activity of your compound in a cellular environment and ensure it can cross the membrane to enter the cells


  • Previous: no more
  • Next: no more
  • Copyright © PharmaCore Labs (PCL) Co., Ltd All rights reserved 备案号:苏ICP备15051795号 欢迎来电咨询! 技术支持:裕福科技