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In vitro cellular level

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iPS-derived cardiomycytes

Time2020-04-20 15:29:55 Hits688

CiPA program requires drug's effect on cardiac ion channels and action potential to be verified in human ventricular iPS (induced pluropotent stem cell)-derived myocytes.

In vitro electrophysiology assay in human iPS-derived ventricular myocytes:

Assay platform/method

Conventional patch clamp

Cells used in the assay

Human iPS-derived ventricular myocytes( IPSC)

Measured parameters

Action potential (APA, APD30/60/90)

Test concentrations

3 doses, 3 stimulation frequency (0.5 Hz, 1 Hz, 1.7 Hz)

Data point repeats

N = 3 for each concentration

Note: 1) Positive control: 0.3 μM Haloperidol is used in the assay to ensure cell quality and normal response of sodium channels.

2) If requested, 1 or 2 stimulation frequency can be selected.

Effect of haloperidol on IPS-derived ventricular myocytes

Effect of terfenadine on IPS-derived ventricular myocytes

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